Elacestrant dihydrochloride

CAS No. 1349723-93-8

Elacestrant dihydrochloride( RAD-1901 dihydrochloride )

Catalog No. M11413 CAS No. 1349723-93-8

Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 224 Get Quote
10MG 356 Get Quote
25MG 599 Get Quote
50MG 852 Get Quote
100MG 1152 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Elacestrant dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
  • Description
    Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD); inhibits ERα expression in MCF-7 cells (IC50=0.6 nM); induces the degradation of ER, inhibits ER-mediated signaling and growth of ER+ breast cancer cell lines in vitro and in vivo, and significantly inhibits tumor growth of multiple PDX models.Breast Cancer Phase 2 Clinical.
  • In Vitro
    Cell Proliferation Assay Cell Line:ER-positive MCF-7 cells (Estradiol (E2)-stimulated)Concentration:0-1 μM Incubation Time:48 h Result:Showed antiproliferative activity on cells.Western Blot Analysis Cell Line:MCF-7 cells Concentration:0.5 nM-10 μM Incubation Time:48 h Result:Inhibited ERα expression (EC50 of 0.6 nM) in a dose-dependent manner.Western Blot AnalysisCell Line:MCF7, T47D, and HCC1428 cells Concentration:0-1 μM Incubation Time:24 or 48 h Result:Decreased the expression of estrogen receptor protein.
  • In Vivo
    ——
  • Synonyms
    RAD-1901 dihydrochloride
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen Receptor/ERR
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1349723-93-8
  • Formula Weight
    531.5568
  • Molecular Formula
    C30H40Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 17.6 mg/mL
  • SMILES
    ——
  • Chemical Name
    2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, hydrochloride (1:2), (6R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wardell SE, et al. Endocr Relat Cancer. 2015 Oct;22(5):713-24. 2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56. 3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
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